Description

4-(3-Trifluoromethylphenyl)Tetrahydropyran-4-Amine is a high-value, fluorinated organic building block featuring a tetrahydropyran scaffold linked to a trifluoromethylphenyl group. This compound is crucial for medicinal chemistry and agrochemical research, where its unique structure imparts desirable physicochemical properties such as enhanced metabolic stability and lipophilicity to target molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, or organic electronic materials due to its rigid, aromatic-fluorinated structure.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Details
Product Name	4-(3-Trifluoromethylphenyl)Tetrahydropyran-4-Amine
CAS No.	1094283-09-6
Molecular Formula	C12H14F3NO
Molecular Weight	245.24 g/mol
Synonyms	4-(3-(Trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-amine; 4-Amino-4-(3-trifluoromethylphenyl)tetrahydropyran; 4-(3-Trifluoromethylphenyl)-4-aminotetrahydropyran; 4-(α,α,α-Trifluoro-m-tolyl)tetrahydropyran-4-amine; 1094283-09-6; 4-(3-Trifluoromethylphenyl)piperidin-4-ol analog (tetrahydropyran); 4-(m-Trifluoromethylphenyl)-4-aminooxane
EINECS	Contact for details

Quality Control

Our 4-(3-Trifluoromethylphenyl)Tetrahydropyran-4-Amine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.