Description

4-(3-Fluorophenyl)Tetrahydro-2H-Pyran-4-Amine is a high-purity fluorinated amine building block of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. Pharmaceutical researchers and fine chemical manufacturers need this material for constructing complex molecules where the fluorophenyl and cyclic amine moieties impart specific biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of central nervous system (CNS) active drugs, kinase inhibitors, and other novel therapeutic agents.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioavailability and target binding.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Material Science: Employed in the synthesis of specialty polymers and advanced organic materials requiring fluorinated aromatic components.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes for studying enzyme mechanisms and protein-ligand interactions in drug discovery.

Basic Information

Product Name	4-(3-Fluorophenyl)Tetrahydro-2H-Pyran-4-Amine
CAS No.	1094283-08-5
Molecular Formula	C11H14FNO
Molecular Weight	195.23 g/mol
Synonyms	4-(3-Fluorophenyl)tetrahydro-2H-pyran-4-amine; 4-Amino-4-(3-fluorophenyl)tetrahydro-2H-pyran; 4-(3-Fluorophenyl)-4-aminotetrahydropyran; 4-(3-Fluorophenyl)tetrahydropyran-4-amine; 4-(3-Fluorophenyl)-4-aminooxane; 1094283-08-5; 4-(3-Fluorophenyl)-4-aminotetrahydro-2H-pyran
EINECS	Contact for details

Quality Control

Our 4-(3-Fluorophenyl)Tetrahydro-2H-Pyran-4-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring the material meets the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.