Description

Carbamic Acid, n-[(1S)-1-[[(Methylsulfonyl)Oxy]Methyl]-2-[(3R)-Tetrahydro-2H-Pyran-3-Yl]Ethyl]-, Phenylmethyl Ester is a sophisticated chiral building block of significant interest in advanced organic synthesis. This compound matters because it serves as a key intermediate for constructing complex molecules, particularly in the pharmaceutical sector where stereochemical purity is paramount. It is primarily needed by research and development chemists and process scale-up teams working on novel active pharmaceutical ingredients (APIs), especially those targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of complex, stereochemically-defined active pharmaceutical ingredients (APIs).
• Process Chemistry: Used in route development and scale-up for the commercial manufacturing of target drug molecules.
• Medicinal Chemistry Research: Enables the exploration of novel chemical space and structure-activity relationships (SAR) in drug discovery programs.
• Asymmetric Synthesis: Serves as a chiral synthon for introducing specific stereocenters into larger molecular frameworks.
• Custom Synthesis: A valuable starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized compounds for clients.
• Chemical Biology: Potential use in the synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	Carbamic Acid, n-[(1S)-1-[[(Methylsulfonyl)Oxy]Methyl]-2-[(3R)-Tetrahydro-2H-Pyran-3-Yl]Ethyl]-, Phenylmethyl Ester
CAS No.	1093869-18-1
Molecular Formula	C17H25NO5S
Molecular Weight	355.45 g/mol
Synonyms	Benzyl N-[(1S)-1-[[(methylsulfonyl)oxy]methyl]-2-[(3R)-oxan-3-yl]ethyl]carbamate; (3R)-3-[(2S)-2-[[(Benzyloxy)carbonyl]amino]-3-[(methylsulfonyl)oxy]propyl]tetrahydro-2H-pyran; Carbamic acid, N-[(1S)-1-[[(methylsulfonyl)oxy]methyl]-2-[(3R)-tetrahydro-2H-pyran-3-yl]ethyl]-, phenylmethyl ester; Chiral Pyranyl Carbamate Mesylate Ester; (S,R)-Benzyl Carbamate Intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high stereochemical purity. Quality is verified through comprehensive analytical methods including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting purity, enantiomeric excess, and impurity profiles to support your regulatory filings and process validation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.