Description

n-[(1R)-1-(Aminomethyl)-2-[(3S)-Tetrahydro-2H-Pyran-3-Yl]Ethyl]-n-Methylcarbamic Acid tert-Butyl Ester is a sophisticated chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other targeted therapeutics. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the production of high-value, small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel protease inhibitor drugs.
• API Development: Serves as a critical precursor in the research and scale-up manufacturing of new chemical entities (NCEs).
• Peptidomimetic Synthesis: Used to construct complex molecular scaffolds that mimic peptide structures for enhanced drug stability and bioavailability.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce specific chiral centers into target molecules.
• Medicinal Chemistry Research: Provides a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	n-[(1R)-1-(Aminomethyl)-2-[(3S)-Tetrahydro-2H-Pyran-3-Yl]Ethyl]-n-Methylcarbamic Acid tert-Butyl Ester
CAS No.	1093865-09-8
Molecular Formula	C15H28N2O3
Molecular Weight	284.40 g/mol
Synonyms	(1R,3S)-1-[(tert-Butoxycarbonyl)(methyl)amino]-3-(tetrahydro-2H-pyran-3-yl)propan-2-amine; tert-Butyl N-[(1R)-1-(aminomethyl)-2-[(3S)-oxan-3-yl]ethyl]-N-methylcarbamate; BOC-Protected Amino Pyran Intermediate; (R,S)-Boc-Protected Diamine Derivative; CAS 1093865-09-8; Chiral Boc-Amine Pyran Building Block; N-Boc-N'-methyl-diamine-tetrahydropyran derivative
EINECS	Contact for details

Quality Control

This high-purity intermediate is manufactured under strict quality systems. Certificates of Analysis (COA) are provided with each batch, detailing key parameters such as chiral purity, chemical purity, and residual solvents. Our quality commitment aligns with ICH Q7 guidelines for active pharmaceutical ingredients, and we support customer audits and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen) when appropriate to maintain stability. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.