Description

2-Bromo-6-(Trimethylsilyl)Phenyl Triflate 95% is a high-purity, advanced organic intermediate featuring both bromo and triflate leaving groups, activated by the ortho-trimethylsilyl substituent. This compound is specifically engineered for complex cross-coupling and metal-catalyzed reactions where precise electronic and steric control is paramount. It is an essential building block for researchers and process chemists in pharmaceutical development, agrochemical synthesis, and advanced materials science, enabling the construction of sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for Suzuki-Miyaura and Stille cross-coupling reactions to introduce complex aryl groups.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific, sterically hindered biaryl structures.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphine or N-heterocyclic carbene (NHC) ligands used in asymmetric catalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) where the bromo and triflate groups allow for sequential functionalization.
• Chemical Biology Probes: Useful for tagging biomolecules or synthesizing probe molecules due to its orthogonal reactivity.

Basic Information

Item	Details
Product Name	2-Bromo-6-(Trimethylsilyl)Phenyl Triflate 95%
CAS No.	1092542-31-8
Molecular Formula	C10H12BrF3O3SSi
Molecular Weight	401.26 g/mol
Synonyms	2-Bromo-6-(trimethylsilyl)phenyl trifluoromethanesulfonate; 2-Bromo-6-(trimethylsilyl)phenyl triflate; (2-Bromo-6-(trimethylsilyl)phenyl) trifluoromethanesulfonate; 1-Bromo-2-(trifluoromethanesulfonyloxy)-3-(trimethylsilyl)benzene; Trifluoromethanesulfonic acid 2-bromo-6-(trimethylsilyl)phenyl ester
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-6-(Trimethylsilyl)Phenyl Triflate 95% is manufactured and tested under a strict quality management system. We guarantee a minimum purity of 95% (typically by HPLC/NMR) and provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality commitment ensures material consistency for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.