Description

(R)-2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-B]Furan-8-Yl)Acetic Acid is a high-purity chiral building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel, stereoselective pharmaceuticals and bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, process chemistry, and the synthesis of complex natural products.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Asymmetric Synthesis: Utilized as a starting material or advanced intermediate in catalytic asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies and the generation of focused compound libraries for biological screening.
• Process Development: Used in scaling up synthetic routes from laboratory to pilot plant scale, requiring consistent high-quality supply.
• Reference Standard: Employed as an analytical standard for method development and quality control in regulatory filings for new drug substances.

Basic Information

Product Name	(R)-2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-B]Furan-8-Yl)Acetic Acid
CAS No.	1092507-02-2
Molecular Formula	C₁₅H₁₆O₃
Molecular Weight	244.29 g/mol
Synonyms	(R)-2-(2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-yl)acetic acid; (8R)-2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-acetic acid; (R)-Indanofuran acetic acid; (R)-THIFA; (R)-Tetrahydroindeno[5,4-b]furan-8-ylacetic acid; (R)-8-Acetic acid-2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan
EINECS	Contact for details

Quality Control

Our (R)-2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-B]Furan-8-Yl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the exacting requirements of pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.