Description

8-Chloro-5-Fluorochroman-4-One is a high-purity fluorinated chromanone derivative, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its value lies in its unique halogenated structure, which is essential for modulating the biological activity and pharmacokinetic properties of target molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used as a precursor in the manufacture of advanced pesticides and herbicides, leveraging its halogenated ring system.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic substitutions, and cyclization reactions to construct complex heterocyclic compounds.
• Material Science Research: Investigated as a monomer or precursor for the synthesis of specialty polymers and functional materials with specific optical or electronic properties.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	8-Chloro-5-Fluorochroman-4-One
CAS No.	1092350-94-1
Molecular Formula	C9H6ClFO2
Molecular Weight	200.59 g/mol
Synonyms	8-Chloro-5-fluorochroman-4-one; 4H-1-Benzopyran-4-one, 8-chloro-5-fluoro-2,3-dihydro-; 8-Chloro-5-fluoro-2,3-dihydro-4H-chromen-4-one; 8-Chloro-5-fluoro-3,4-dihydro-2H-1-benzopyran-4-one; 5-Fluoro-8-chlorochroman-4-one; Chroman-4-one, 8-chloro-5-fluoro-
EINECS	Contact for details

Quality Control

Our 8-Chloro-5-Fluorochroman-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.