Description

8-Amino-5-Fluorochroman-4-One is a high-purity fluorinated chromanone derivative, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its value lies in the strategic incorporation of both fluorine and amino functional groups, which are essential for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used as a precursor in the creation of novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the fluorine atom.
• Organic Synthesis Building Block: Employed in complex organic transformations, including cyclization and coupling reactions, to construct more elaborate heterocyclic frameworks.
• Chemical Research & Development: Serves as a standard or reference material in analytical laboratories and for method development in quality control settings.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals and functional materials requiring specific fluorinated chromanone structures.

Basic Information

Product Name	8-Amino-5-Fluorochroman-4-One
CAS No.	1092350-49-6
Molecular Formula	C9H8FNO2
Molecular Weight	181.16 g/mol
Synonyms	5-Fluoro-8-aminochroman-4-one; 4H-1-Benzopyran-4-one, 8-amino-5-fluoro-2,3-dihydro-; 8-Amino-5-fluoro-3,4-dihydro-2H-1-benzopyran-4-one; 5-Fluoro-8-amino-3,4-dihydro-2H-chromen-4-one; 8-Amino-5-fluoro-4-chromanone; 5-Fluoro-8-amino-4-chromanone; 1092350-49-6; 8-Amino-5-fluorochroman-4-one
EINECS	Contact for details

Quality Control

Our 8-Amino-5-Fluorochroman-4-One is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.