Description

6-Chloro-8-Fluorochroman-4-One is a high-purity fluorinated chromanone derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its unique halogenated structure, which is essential for modulating the biological activity and pharmacokinetic properties of target drug molecules. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize new chemical entities for drug discovery programs.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for candidate drugs under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Synthesis: Potential intermediate in the development of novel herbicides or pesticides, leveraging its halogenated aromatic system.
• Material Science Precursor: Can be utilized in the synthesis of specialized organic ligands or fluorinated polymers for advanced materials.

Basic Information

Product Name	6-Chloro-8-Fluorochroman-4-One
CAS No.	1092350-27-0
Molecular Formula	C9H6ClFO2
Molecular Weight	200.59 g/mol
Synonyms	6-Chloro-8-fluoro-4-chromanone; 4H-1-Benzopyran-4-one, 6-chloro-8-fluoro-2,3-dihydro-; 6-Chloro-8-fluoro-3,4-dihydro-2H-1-benzopyran-4-one; 6-Chloro-8-fluoro-2,3-dihydro-4H-chromen-4-one; 6-Chloro-8-fluorochroman-4-one; 6-Chloro-8-fluoro-4-chromanone; 1092350-27-0; 6-Chloro-8-fluoro-3,4-dihydro-2H-chromen-4-one
EINECS	Contact for details

Quality Control

Our 6-Chloro-8-Fluorochroman-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.