Description

8-Bromo-5-Fluoro-2,3-Dihydro-4H-Chromen-4-One is a high-purity fluorinated and brominated chromenone derivative, serving as a critical advanced intermediate for pharmaceutical research and development. Its unique halogenated structure makes it a valuable scaffold for constructing complex molecules with targeted biological activity. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging its halogenated heterocyclic core.
• Chemical Biology Probe: Serves as a precursor for fluorescent tags or molecular probes to study enzyme activity and biological pathways.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and organic electronic materials due to its fused ring system.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	8-Bromo-5-Fluoro-2,3-Dihydro-4H-Chromen-4-One
CAS No.	1092348-60-1
Molecular Formula	C9H6BrFO2
Molecular Weight	245.05 g/mol
Synonyms	8-Bromo-5-fluorochroman-4-one; 5-Fluoro-8-bromo-2,3-dihydro-4H-chromen-4-one; 8-Bromo-5-fluoro-3,4-dihydro-2H-1-benzopyran-4-one; 8-Bromo-5-fluoro-4-chromanone; 4H-1-Benzopyran-4-one, 8-bromo-5-fluoro-2,3-dihydro-; 1092348-60-1; 8-Br-5-F-chroman-4-one
EINECS	Contact for details

Quality Control

Our 8-Bromo-5-Fluoro-2,3-Dihydro-4H-Chromen-4-One is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.