Description

n-[(1R,2R)-2-Amino-1,2-Diphenylethyl]-N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea is a chiral thiourea derivative that functions as a highly effective organocatalyst. This compound matters for its ability to facilitate asymmetric synthesis with excellent enantioselectivity, enabling the production of optically pure intermediates critical for advanced materials and pharmaceuticals. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries seeking robust and selective catalytic solutions.

Application

• Asymmetric Organocatalysis: Employed as a chiral catalyst for a variety of enantioselective transformations, including Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate Synthesis: Key for constructing chiral centers in the development of active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Research: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool compound for methodological development in synthetic organic chemistry laboratories.
• Ligand for Metal Complexes: Can act as a precursor or auxiliary ligand in the preparation of chiral metal complexes for catalysis.

Basic Information

Product Name	n-[(1R,2R)-2-Amino-1,2-Diphenylethyl]-N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea
CAS No.	1088705-53-6
Molecular Formula	C23H19F6N3S
Molecular Weight	483.47 g/mol
Synonyms	(1R,2R)-N1-[3,5-Bis(trifluoromethyl)phenyl]-N2-(2-amino-1,2-diphenylethyl)thiourea; (R,R)-Thiourea, N-[(1,2-diphenyl-2-aminoethyl)]-N'-[3,5-bis(trifluoromethyl)phenyl]-; Takemoto Catalyst; (R,R)-Takemoto's Thiourea Organocatalyst; (1R,2R)-DPEN-Derived Thiourea Catalyst; Chiral Bifunctional Thiourea Catalyst
EINECS	Contact for details

Quality Control

Our production of n-[(1R,2R)-2-Amino-1,2-Diphenylethyl]-N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by advanced analytical techniques, including chiral HPLC, to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.