Description

(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-Chloro-3-(4-Hydroxybenzyl)Phenyl)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate is a high-purity, synthetically derived chemical intermediate with a complex stereochemistry that is critical for its biological activity. This compound is valued for its role as a key building block in advanced pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating targeted molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) for new drug candidates.
• Biochemical Research: Used as a standard or reagent in enzymatic and receptor-binding studies due to its specific stereochemical configuration.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex organic molecules.
• Glycoscience Research: Acts as a protected glycosyl donor or acceptor analog in carbohydrate chemistry for developing glycoconjugates.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to explore and optimize biological activity profiles.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-Chloro-3-(4-Hydroxybenzyl)Phenyl)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate
CAS No.	1079083-63-8
Molecular Formula	C31H33ClO10
Molecular Weight	601.04 g/mol
Synonyms	Dapagliflozin Impurity 38; Dapagliflozin Related Compound 38; 1-Chloro-4-(β-D-glucopyranos-1-yl)-2-(4-hydroxybenzyl)benzene 2,3,4,6-Tetraacetate; (2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-[4-chloro-3-[(4-hydroxyphenyl)methyl]phenyl]tetrahydro-2H-pyran-3,4,5-triyl triacetate; BMS-512148 Impurity; Forxiga Impurity; SGLT2 Inhibitor Intermediate; 1,2,3,4,6-Penta-O-acetyl-β-D-glucopyranose derivative
EINECS	Contact for details

Quality Control

Our production of (2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-Chloro-3-(4-Hydroxybenzyl)Phenyl)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate adheres to stringent quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements, supporting development under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.