Description

4-Pentynyl Methanethiosulfonate is a specialized alkyne-functionalized thiosulfonate reagent, a critical building block for bioconjugation and chemical biology research. Its core value lies in its ability to serve as a highly selective and efficient cross-linking agent, particularly for the modification of cysteine residues in proteins and peptides under mild conditions. This compound is essential for researchers and manufacturers in the fields of pharmaceutical development, proteomics, and advanced material science, where precise and stable molecular labeling is required.

Application

• Bioconjugation and Protein Labeling: Selective modification of cysteine residues in antibodies, enzymes, and other therapeutic proteins for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Chemical Biology Probes: Synthesis of activity-based probes (ABPs) for studying enzyme function and target engagement in drug discovery.
• Surface Functionalization: Immobilization of biomolecules onto gold nanoparticles, biosensors, or microarray surfaces via thiol-gold chemistry.
• Polymer Chemistry: Serving as a functional monomer or cross-linker in the synthesis of smart polymers and hydrogels with tailored properties.
• Peptide Synthesis: Introduction of stable thioether linkages or fluorescent tags during solid-phase peptide synthesis (SPPS).
• Materials Science: Creating self-assembled monolayers (SAMs) and modifying material interfaces for enhanced biocompatibility or specific interactions.

Basic Information

Product Name	4-Pentynyl Methanethiosulfonate
CAS No.	1076199-31-9
Molecular Formula	C6H10O2S2
Molecular Weight	178.27 g/mol
Synonyms	Methanesulfonothioic acid S-(4-pentynyl) ester; S-(Pent-4-yn-1-yl) methanethiosulfonate; 4-Pentynyl MTS; Pent-4-yn-1-yl methanesulfonothioate; Alkyne-MTS; Propargyl-PEG4-MTS; (4-Pentynylthio)methanesulfonate; S-(4-Pentynyl) methanethiosulfonate
EINECS	Contact for details

Quality Control

Our 4-Pentynyl Methanethiosulfonate is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to verify identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at -20°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.