Description

4-Methylumbelliferyl Methanethiosulfonate is a specialized biochemical reagent primarily used as a fluorogenic substrate for labeling and detection applications. This compound is valued for its ability to react selectively with thiol groups, generating a highly fluorescent 4-methylumbelliferone product. It is an essential tool for researchers and manufacturers in the fields of bioconjugation, enzyme activity assays, and diagnostic kit development, particularly for probing cysteine residues in proteins and peptides.

Application

• Bioconjugation Reagent: For site-specific labeling of cysteine-containing proteins and antibodies with fluorescent tags.
• Enzyme Activity Assays: As a fluorogenic substrate for thiol-dependent enzymes, such as certain proteases and transferases.
• Diagnostic Development: Used in the formulation of fluorescent detection systems for clinical diagnostics and research kits.
• Chemical Biology Probes: For studying protein function, localization, and interactions through thiol-reactive fluorescence turn-on.
• Pharmaceutical Research: In drug discovery for screening and characterizing compounds that interact with thiol groups.
• Material Science: For surface functionalization and creating fluorescently labeled polymers or nanoparticles.

Basic Information

Product Name	4-Methylumbelliferyl Methanethiosulfonate
CAS No.	1076198-63-4
Molecular Formula	C11H10O5S2
Molecular Weight	286.32 g/mol
Synonyms	4-Methylumbelliferyl MTS; MUMTS; 4-MU MTS; 7-Hydroxy-4-methylcoumarin methanethiosulfonate; 4-Methyl-7-hydroxycoumarin methanethiosulfonate; 4-Methylumbelliferone methanethiosulfonate; MTSEA-4MU; Thiol-reactive fluorogenic coumarin derivative
EINECS	Contact for details

Quality Control

Our 4-Methylumbelliferyl Methanethiosulfonate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and diagnostic applications. Each lot is characterized by advanced analytical techniques, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.