Description

Potassium 1-Boc-6-Chloroindole-2-Trifluoroborate is a high-value organotrifluoroborate salt, a protected and stabilized synthetic intermediate crucial for modern cross-coupling reactions. Its primary value lies in enabling the efficient and selective construction of complex indole-based molecules, which are privileged scaffolds in medicinal chemistry. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and advanced materials. The product is supplied with CAS No. 1073468-33-3.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those containing functionalized indole cores.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air- and moisture-tolerant boronic acid surrogate for palladium-catalyzed carbon-carbon bond formation.
• Medicinal Chemistry Research: Enables rapid parallel synthesis and structure-activity relationship (SAR) studies for lead optimization.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with indole-based structures.
• Material Science: Potential precursor for creating organic electronic materials and advanced polymers with specific optoelectronic properties.
• Process Chemistry: Employed in the scale-up and development of robust, cost-effective manufacturing routes for complex molecules.

Basic Information

Product Name	Potassium 1-Boc-6-Chloroindole-2-Trifluoroborate
CAS No.	1073468-33-3
Molecular Formula	C₁₃H₁₃BClF₃KNO₂
Molecular Weight	359.61 g/mol
Synonyms	Potassium (1-((tert-Butoxy)carbonyl)-6-chloro-1H-indol-2-yl)trifluoroborate; 1-Boc-6-Chloroindole-2-Trifluoroborate Potassium Salt; 6-Chloro-1-Boc-indole-2-trifluoroborate Potassium; Potassium 6-Chloro-1-(tert-butoxycarbonyl)-1H-indole-2-trifluoroborate; 2-Trifluoroborato-6-chloro-1-Boc-indole Potassium Salt; 1H-Indole-2-boronic acid, 6-chloro-1-[(1,1-dimethylethoxy)carbonyl]-, potassium trifluoroborate(1-); Potassium (6-Chloro-1-((tert-butoxycarbonyl)indol-2-yl)trifluoroborate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. Standard quality control includes assessment of purity (by NMR and HPLC), identity confirmation, and quantification of key impurities. Certificates of Analysis (COA) detailing all specifications and test results are available upon request. We adhere to strict in-process controls to deliver material suitable for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.