Description

3-Fluoro-4-(n-Morpholinomethyl)Phenylboronic Acid, Pinacol Ester is a sophisticated boronic ester derivative, a crucial intermediate in modern synthetic chemistry. Its value lies in its enhanced stability and reactivity, making it a superior building block for constructing complex molecules compared to its free acid counterpart. This compound is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for applications such as Suzuki-Miyaura cross-coupling reactions.

Application

This high-value boronic ester is a versatile synthon designed for advanced chemical synthesis. Its primary and related applications include:

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing fluorinated aromatic systems and morpholine motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science Research: Employed in the creation of advanced organic materials, such as organic light-emitting diodes (OLEDs) and liquid crystals, where precise molecular architecture is critical.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-tolerant organoboron reagent for forming carbon-carbon bonds between aromatic rings, a fundamental reaction in medicinal and process chemistry.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and inhibitors for studying biological pathways and enzyme functions.

Basic Information

Product Name	3-Fluoro-4-(n-Morpholinomethyl)Phenylboronic Acid, Pinacol Ester
CAS No.	1073354-74-1
Molecular Formula	C17H25BFNO3
Molecular Weight	321.20 g/mol
Synonyms	4-(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)morpholine; 2-[3-Fluoro-4-(morpholin-4-ylmethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Fluoro-4-(morpholinomethyl)phenylboronic acid pinacol ester; (3-Fluoro-4-(morpholinomethyl)phenyl)boronic acid pinacol ester; Pinacol 3-Fluoro-4-(morpholinomethyl)benzeneboronate; B-[3-Fluoro-4-(morpholinomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our production of 3-Fluoro-4-(n-Morpholinomethyl)Phenylboronic Acid, Pinacol Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing results from NMR (1H, 13C, 19F, 11B), HPLC, and other relevant tests are provided to guarantee the material meets your specific research or process requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.