Description

n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1S,2S)-2-[(11Br)-3,5-Dihydro-4H-Dinaphth[2,1-C:1',2'-E]Azepin-4-Yl]-1,2-Diphenylethyl]- Thiourea is a sophisticated chiral thiourea derivative designed for high-performance applications in asymmetric synthesis and catalysis. This compound matters for its role as a highly selective organocatalyst, enabling precise stereochemical control in complex pharmaceutical and fine chemical manufacturing processes. It is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for cutting-edge research and production.

Application

• Asymmetric Organocatalysis: Serving as a privileged chiral scaffold for catalyzing enantioselective reactions, such as Michael additions, aldol reactions, and acylations.
• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Ligand for Metal Complexes: Potential use in designing chiral ligands for transition metal catalysis, enhancing selectivity in cross-coupling and hydrogenation reactions.
• Agrochemical Research: Employed in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science: Investigation into chiral dopants for liquid crystals or as a component in advanced polymeric materials requiring specific stereochemistry.
• Academic & Industrial R&D: A valuable tool compound for methodological development in organic synthesis and catalysis studies.

Basic Information

Item	Detail
Product Name	n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1S,2S)-2-[(11Br)-3,5-Dihydro-4H-Dinaphth[2,1-C:1',2'-E]Azepin-4-Yl]-1,2-Diphenylethyl]- Thiourea
CAS No.	1069114-12-0
Molecular Formula	C46H31BrF6N3S
Molecular Weight	843.72 g/mol
Synonyms	(1S,2S)-N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2-(11-bromo-4,5-dihydro-3H-dinaphtho[2,1-c:1',2'-e]azepin-4-yl)-1,2-diphenylethyl]thiourea; (S,S)-Br-DTBM-SEGPHOS-Based Thiourea Catalyst; Chiral Bis(trifluoromethyl)phenyl Thiourea Derivative; Asymmetric Thiourea Organocatalyst; N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(1S,2S)-2-(11-bromo-4,5-dihydro-3H-dinaphtho[2,1-c:1',2'-e]azepin-4-yl)-1,2-diphenylethyl]thiourea
EINECS	Contact for details

Quality Control

Every batch of our chiral thiourea compound is produced and analyzed under strict quality management protocols to ensure exceptional purity and stereochemical integrity. Standard quality control includes HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97%), enantiomeric excess (ee), and related substances is provided with each shipment to support your GMP-ready or research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation from moisture uptake. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.