Description

n-[(8α,9S)-6'-Methoxycinchonan-9-Yl]-N'-[(2S)-2-Pyrrolidinylmethyl]-Thiourea is a sophisticated chiral thiourea derivative, a class of compounds renowned for their utility as organocatalysts and ligands in asymmetric synthesis. This high-purity compound is engineered to deliver exceptional enantioselectivity and yield in critical chemical transformations, directly addressing the need for reliable and efficient chiral induction. It is an essential reagent for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• Asymmetric Organocatalysis: Employed as a powerful hydrogen-bond donor catalyst for enantioselective reactions such as Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of chiral active pharmaceutical ingredients (APIs) where high enantiomeric purity is mandatory.
• Ligand for Metal Complexes: Serves as a chiral ligand to modify metal catalysts for asymmetric hydrogenation and other transition metal-catalyzed processes.
• Fine Chemical Production: Facilitates the synthesis of complex, enantiomerically pure molecules for agrochemicals, flavors, and fragrances.
• Academic & Industrial R&D: A valuable tool for methodological development in synthetic organic chemistry laboratories.

Basic Information

Product Name	n-[(8α,9S)-6'-Methoxycinchonan-9-Yl]-N'-[(2S)-2-Pyrrolidinylmethyl]-Thiourea
CAS No.	1068504-58-4
Molecular Formula	C26H34N4O2S
Molecular Weight	466.64 g/mol
Synonyms	(8α,9S)-N-[(2S)-2-Pyrrolidinylmethyl]-6'-methoxycinchonan-9-amine thiourea derivative; Cinchona-based thiourea organocatalyst; (S,S)-Cinchona thiourea catalyst; Chiral bifunctional thiourea; 9-Thiourea-10,11-dihydro-6'-methoxycinchonane; (9S)-N-[(2S)-1-Pyrrolidinylmethyl]-6'-methoxycinchonan-9-amine carbothioamide; Asymmetric synthesis catalyst 1068504-58-4
EINECS	Contact for details

Quality Control

Our production of this advanced chiral compound adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Every lot is characterized using advanced analytical techniques, including HPLC for purity and chiral purity assessment, and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profile is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.