Description

2-Bromo-5-(Tributylstannyl)Thiazole is a high-purity organotin reagent, a crucial building block in modern synthetic chemistry. Its value lies in enabling efficient Stille cross-coupling reactions, a powerful method for forming carbon-carbon bonds under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to construct complex heterocyclic scaffolds and functionalized molecules.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for constructing thiazole-containing drug candidates in oncology, antiviral, and anti-infective research.
• Agrochemical Synthesis: Used to create advanced fungicides, herbicides, and insecticides by introducing the thiazole moiety into target molecules via palladium-catalyzed coupling.
• Material Science Research: Employed in the development of organic semiconductors, conductive polymers, and liquid crystals, where precise molecular architecture is critical for electronic properties.
• Chemical Biology & Probe Development: Facilitates the site-specific labeling of biomolecules and the synthesis of molecular probes for diagnostic and imaging applications.
• Cross-Coupling Methodology: Serves as a standard organotin reagent in method development and optimization studies for Stille coupling reactions in academic and industrial R&D laboratories.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex, patent-protected molecules for clients.

Basic Information

Product Name	2-Bromo-5-(Tributylstannyl)Thiazole
CAS No.	1062589-73-4
Molecular Formula	C15H28BrNSSn
Molecular Weight	469.04 g/mol
Synonyms	5-(Tributylstannyl)-2-bromothiazole; 2-Bromo-5-tributylstannanylthiazole; Thiazole, 2-bromo-5-(tributylstannyl)-; Tributyl(5-bromothiazol-2-yl)stannane; Stannane, tributyl(5-bromothiazol-2-yl)-; 2-Bromo-5-(tributylstannyl)thiazole; 5-Bromo-2-(tributylstannyl)thiazole (isomeric); Organotin reagent 1062589-73-4
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-(Tributylstannyl)Thiazole is produced and analyzed under strict quality management protocols. We employ advanced analytical techniques including NMR (1H, 13C, 119Sn), HPLC, and GC to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated place. Keep away from heat, sparks, and open flame. Due to the moisture-sensitive and light-sensitive nature of organotin compounds, containers should be allowed to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Area %)
1H NMR Purity	Conforms
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.