Description

m-Peg13-Ms is a high-purity, monodisperse polyethylene glycol (PEG) derivative functionalized with a methanesulfonate (mesylate) group. This compound serves as a critical bifunctional linker in advanced organic synthesis and bioconjugation, enabling the precise attachment of molecules to surfaces or other biomolecules. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require controlled PEGylation to enhance solubility, stability, and pharmacokinetic properties of therapeutic agents.

Application

• Pharmaceutical PEGylation: A key reagent for attaching polyethylene glycol chains to peptides, proteins, and oligonucleotides to improve drug delivery and reduce immunogenicity.
• Bioconjugation & Linker Chemistry: Used as a heterobifunctional crosslinker to connect biomolecules, nanoparticles, or polymers via its reactive mesylate and hydroxyl termini.
• ADC (Antibody-Drug Conjugate) Development: Facilitates the construction of stable, cleavable, or non-cleavable linkers between antibodies and cytotoxic payloads.
• Surface Functionalization: Employed to modify nanoparticles, quantum dots, and biosensor surfaces with PEG spacers for reduced non-specific binding and improved biocompatibility.
• Polymer & Dendrimer Synthesis: Acts as a controlled building block for creating well-defined, branched, or linear polymeric architectures.
• Diagnostic Reagent Preparation: Used in the development of contrast agents, fluorescent probes, and assay components requiring hydrophilic spacing.

Basic Information

Product Name	m-Peg13-Ms
CAS No.	1059604-93-1
Molecular Formula	C28H58O16S
Molecular Weight	682.8 g/mol
Synonyms	Methoxy-PEG13-mesylate; α-Methoxy-ω-mesyl-pentaethylene glycol; mPEG13-Ms; Methoxypolyethylene glycol (13) mesylate; 2,5,8,11,14,17,20,23,26,29,32,35,38-Tridecaoxatetracontan-40-yl methanesulfonate; Monomethoxy PEG13 mesylate; PEG13 methyl ether mesylate; (3,6,9,12,15,18,21,24,27,30,33,36,39-Tridecaoxahentetracontan-1-yl) methanesulfonate
EINECS	Contact for details

Quality Control

Our m-Peg13-Ms is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, supporting its use in research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	680 - 686 g/mol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.