Description

(4R)-7-Chloro-3,4-Dihydro-2H-1-Benzopyran-4-Amine is a chiral benzopyran derivative, a high-purity organic intermediate of significant importance in advanced pharmaceutical synthesis. Its value lies in its role as a key building block for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and cardiovascular disorders. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of enantiomerically pure therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of complex drug candidates.
• API Development: Used in research and development for constructing the core scaffold of potential new chemical entities (NCEs).
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce stereochemical complexity.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Reference Standard: Can be utilized as an analytical standard for method development and quality control in pharmaceutical manufacturing.
• Chemical Biology Probes: Potential use in the development of molecular probes for studying biological pathways.

Basic Information

Product Name	(4R)-7-Chloro-3,4-Dihydro-2H-1-Benzopyran-4-Amine
CAS No.	1057246-81-7
Molecular Formula	C9H10ClNO
Molecular Weight	183.63 g/mol
Synonyms	(4R)-7-Chloro-3,4-dihydro-2H-chromen-4-amine; (4R)-7-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine; 7-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine, (4R)-; (R)-7-Chloro-3,4-dihydro-2H-chromen-4-amine; (R)-7-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine; 4-Amino-7-chloro-3,4-dihydro-2H-chromene, (4R)-; 1057246-81-7
EINECS	Contact for details

Quality Control

Our (4R)-7-Chloro-3,4-Dihydro-2H-1-Benzopyran-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.