Description

(4R)-6-Bromo-3,4-Dihydro-2H-Chromen-4-Amine is a chiral, brominated chromane derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceutical agents, particularly in the synthesis of complex molecules with potential biological activity. Pharmaceutical R&D laboratories and fine chemical manufacturers need this high-purity intermediate to support drug discovery programs targeting central nervous system disorders, cardiovascular diseases, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Asymmetric Synthesis: Utilized in stereoselective synthesis to construct complex molecular architectures due to its defined (4R) stereochemistry.
• Medicinal Chemistry Research: Serves as a core scaffold for generating compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Used in the development of molecular probes to study enzyme mechanisms and biological pathways.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for candidate drugs.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	(4R)-6-Bromo-3,4-Dihydro-2H-Chromen-4-Amine
CAS No.	1055949-66-0
Molecular Formula	C9H10BrNO
Molecular Weight	228.09 g/mol
Synonyms	(4R)-6-Bromo-3,4-dihydro-2H-1-benzopyran-4-amine; (R)-6-Bromo-3,4-dihydro-2H-chromen-4-amine; 6-Bromo-3,4-dihydro-2H-chromen-4-amine, (4R)-; 2H-1-Benzopyran-4-amine, 6-bromo-3,4-dihydro-, (4R)-; (4R)-6-Bromo-3,4-dihydro-2H-chromen-4-ylamine; (R)-6-Bromo-4-aminochroman; (R)-6-Bromo-4-amino-3,4-dihydro-2H-chromene
EINECS	Contact for details

Quality Control

Our (4R)-6-Bromo-3,4-Dihydro-2H-Chromen-4-Amine is manufactured under strict quality control protocols to ensure high chemical and chiral purity, essential for sensitive pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and process development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.