Description

n-[(1R,2R)-2-Aminocyclohexyl]-N'-(8α,9S)-Cinchonan-9-Yl-Thiourea is a sophisticated chiral thiourea derivative, structurally derived from cinchona alkaloids. This compound is of significant interest as a high-performance organocatalyst and a key chiral building block in asymmetric synthesis. It is primarily utilized by research and development teams in the pharmaceutical and fine chemical industries for the enantioselective construction of complex molecules.

Application

• Asymmetric Organocatalysis: Employed as a bifunctional catalyst for a variety of enantioselective reactions, including Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate: Serves as a critical chiral scaffold in the research and development of new active pharmaceutical ingredients (APIs) with specific stereochemistry.
• Ligand Synthesis: Used as a precursor for developing novel chiral ligands for transition metal catalysis.
• Academic & Industrial Research: A valuable tool compound for methodological development in synthetic organic chemistry laboratories.
• Chiral Resolution Agent: Potential application in the separation of enantiomers via diastereomeric salt formation or chromatography.

Basic Information

Product Name	n-[(1R,2R)-2-Aminocyclohexyl]-N'-(8α,9S)-Cinchonan-9-Yl-Thiourea
CAS No.	1052184-44-7
Molecular Formula	C₂₅H₃₄N₄OS
Molecular Weight	438.63 g/mol
Synonyms	(1R,2R)-N-[(8S,9R)-Cinchonan-9-yl]-N'-(2-aminocyclohexyl)thiourea; (1R,2R)-2-Amino-N-[(8S,9R)-cinchonan-9-yl]-N'-cyclohexylthiourea; Cinchona Alkaloid Thiourea Derivative; (R,R)-DACH-Cinchona Thiourea; Asymmetric Thiourea Organocatalyst; 1052184-44-7; (1R,2R)-2-Amino-N-[(8S,9R)-cinchonan-9-yl]-N'-cyclohexylcarbamothioic amide
EINECS	Contact for details

Quality Control

Our production of this advanced chiral compound adheres to stringent quality protocols. Every batch is characterized and tested to ensure high chiral purity and chemical integrity, with specifications tailored for research and process development use. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.