Description

n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(2S)-2-(Dimethylamino)-3-Methylbutyl]- Thiourea is a high-purity, chiral thiourea derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated organocatalyst and a key pharmaceutical intermediate, enabling the precise construction of complex molecules. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and fine chemicals.

Application

• Asymmetric Organocatalysis: Acts as a chiral hydrogen-bond donor catalyst for enantioselective synthesis, particularly in Michael additions and other C-C bond-forming reactions.
• Pharmaceutical Intermediate: Serves as a critical building block in the research and development of novel active pharmaceutical ingredients (APIs) with specific stereochemistry.
• Agrochemical Synthesis: Used in the development of advanced, chiral pesticides and herbicides where specific enantiomer activity is required.
• Ligand for Metal Complexes: Can function as a precursor or auxiliary ligand in the preparation of chiral metal catalysts.
• Chemical Biology Research: Employed as a molecular tool or probe to study enzyme inhibition and biological recognition processes.
• Material Science: Investigated for the synthesis of specialized polymers or functional materials with unique properties.

Basic Information

Item	Detail
Product Name	n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(2S)-2-(Dimethylamino)-3-Methylbutyl]- Thiourea
CAS No.	1048692-60-9
Molecular Formula	C16H19F6N3S
Molecular Weight	415.40 g/mol
Synonyms	(S)-N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2-(dimethylamino)-3-methylbutyl]thiourea; (2S)-N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2-(dimethylamino)-3-methylbutyl]thiourea; Chiral Thiourea Catalyst; N-(3,5-Bis(trifluoromethyl)phenyl)-N'-((2S)-2-(dimethylamino)-3-methylbutyl)thiourea; (S)-1-(3,5-Bis(trifluoromethyl)phenyl)-3-(2-(dimethylamino)-3-methylbutyl)thiourea; Organocatalyst 1048692-60-9; Takemoto Catalyst Derivative
EINECS	Contact for details

Quality Control

Our n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(2S)-2-(Dimethylamino)-3-Methylbutyl]- Thiourea is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for chiral purity and chemical assay, to ensure compliance with exacting research and development standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from moisture and direct light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.