Description

n-[(1R,2R)-2-(Dimethylamino)Cyclohexyl]-N'-[(1R,2S)-2-Hydroxy-1,2-Diphenylethyl]-Thiourea is a sophisticated chiral thiourea derivative, a class of compounds renowned for their utility as organocatalysts and ligands in asymmetric synthesis. Its precise stereochemistry and bifunctional structure make it a valuable tool for researchers and manufacturers requiring high enantioselectivity in chemical transformations. This compound is primarily targeted at the pharmaceutical and fine chemical industries for the development of chiral active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• As a highly effective bifunctional organocatalyst for enantioselective reactions, including Michael additions and aldol condensations.
• As a chiral ligand in metal-catalyzed asymmetric synthesis for constructing complex molecular architectures.
• In pharmaceutical research and development for the synthesis of chiral drug candidates and active pharmaceutical ingredients (APIs).
• For process development and optimization in fine chemical and custom synthesis manufacturing.
• As a key intermediate in the preparation of more complex, functionally diverse chiral thiourea compounds.
• In academic research focused on novel catalytic methodologies and reaction mechanism studies.

Basic Information

Product Name	n-[(1R,2R)-2-(Dimethylamino)Cyclohexyl]-N'-[(1R,2S)-2-Hydroxy-1,2-Diphenylethyl]-Thiourea
CAS No.	1046493-36-0
Molecular Formula	C23H31N3OS
Molecular Weight	397.58 g/mol
Synonyms	(1R,2R)-N1-[(1R,2S)-1,2-Diphenyl-2-hydroxyethyl]-N2-(2-(dimethylamino)cyclohexyl)thiourea; (R,R)-N-[(R,S)-1,2-Diphenyl-2-hydroxyethyl]-N'-[2-(dimethylamino)cyclohexyl]thiourea; Chiral Thiourea Organocatalyst; Bifunctional Thiourea Catalyst; Takemoto Catalyst Derivative; Asymmetric Synthesis Catalyst; (1R,2R)-2-(Dimethylamino)cyclohexylamine thiourea derivative
EINECS	Contact for details

Quality Control

Our production of this advanced chiral compound adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98%), chiral purity, and residual solvent levels is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.