Description

n-[(1R,2R)-2-(Dimethylamino)Cyclohexyl]-N'-[(1S,2R)-2-Hydroxy-1,2-Diphenylethyl]-Thiourea is a sophisticated chiral thiourea derivative designed for advanced chemical synthesis and research. This compound is valued for its role as a highly effective organocatalyst, particularly in enantioselective transformations where precise stereochemical control is paramount. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for the development of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Asymmetric Organocatalysis: Serves as a privileged catalyst for a wide range of enantioselective reactions, including Michael additions, aldol reactions, and Mannich-type reactions.
• Pharmaceutical Intermediate Synthesis: Enables the stereocontrolled construction of chiral centers in the development of new drug candidates and active pharmaceutical ingredients (APIs).
• Methodology Development in Academic Research: A key reagent for exploring new catalytic pathways and reaction mechanisms in university and institutional laboratories.
• Fine Chemical Production: Used in the pilot-scale and commercial-scale synthesis of high-value, optically pure specialty chemicals and agrochemical intermediates.
• Ligand for Metal Complexes: Can act as a chiral ligand precursor for transition metal catalysts, expanding its utility in coordination chemistry and catalysis.

Basic Information

Product Name	n-[(1R,2R)-2-(Dimethylamino)Cyclohexyl]-N'-[(1S,2R)-2-Hydroxy-1,2-Diphenylethyl]-Thiourea
CAS No.	1046493-35-9
Molecular Formula	C23H31N3OS
Molecular Weight	397.58 g/mol
Synonyms	(1R,2R)-N-[(Dimethylamino)cyclohexyl]-N'-(1S,2R)-2-Hydroxy-1,2-diphenylethylthiourea; (R,R)-N-(2-(Dimethylamino)cyclohexyl)-N'-(1S,2R)-2-Hydroxy-1,2-diphenylethyl)thiourea; Takemoto Catalyst; Chiral Thiourea Organocatalyst; (1R,2R)-N1-(2-(Dimethylamino)cyclohexyl)-N2-((1S,2R)-2-hydroxy-1,2-diphenylethyl)thiourea
EINECS	Contact for details

Quality Control

Every batch of our chiral thiourea catalyst is produced under strict quality control protocols to ensure exceptional purity and stereochemical integrity, critical for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as enantiomeric excess (ee), chemical purity, and identity confirmation. Our quality systems support compliance with cGMP standards for advanced pharmaceutical applications, ensuring traceability and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and catalytic activity. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.