Description

3-Chloro-Cyclohexylamine is a versatile chiral amine building block featuring a cyclohexane ring substituted with both an amine and a chloro functional group. This unique structure makes it a critical intermediate for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by research and development chemists and process scale-up teams for creating active pharmaceutical ingredients (APIs), advanced agrochemicals, and specialty fine chemicals. The compound's defined stereochemistry and reactive sites enable precise molecular construction for high-value applications.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of central nervous system (CNS) drugs, antiviral agents, and other bioactive molecules.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and plant growth regulators requiring specific stereochemistry.
• Ligand and Catalyst Preparation: Used in the synthesis of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Intermediate for dyes, pigments, and advanced polymer additives.
• Academic and Industrial Research: Valuable reagent for methodological studies in organic synthesis and medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for bespoke chemical manufacturing projects.

Basic Information

Product Name	3-Chloro-Cyclohexylamine
CAS No.	1045859-81-1
Molecular Formula	C6H12ClN
Molecular Weight	133.62 g/mol
Synonyms	3-Chlorocyclohexanamine; Cyclohexanamine, 3-chloro-; 3-Chloro-1-cyclohexylamine; (3-Chlorocyclohexyl)amine; trans-3-Chlorocyclohexylamine; cis-3-Chlorocyclohexylamine; 3-Chloro-cyclohexylamine hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our 3-Chloro-Cyclohexylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. We provide detailed Certificates of Analysis (COA) with each shipment, documenting key parameters such as chemical identity, assay purity, enantiomeric excess, and impurity profiles. Our quality commitment supports compliance in cGMP and ISO-guided environments for research and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The amine functionality may make it hygroscopic (moisture-sensitive) and potentially reactive with strong oxidizing agents. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% (or as specified)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Specific Rotation	Provided on COA
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.