Description

Leucine, n-[(2-Fluorophenyl)Sulfonyl]- is a specialized fluorinated sulfonamide derivative of the essential amino acid leucine, designed for advanced synthetic applications. This compound is valued for its role as a key building block in medicinal chemistry, where its unique structure facilitates the development of novel bioactive molecules. It is primarily sought by research institutions and pharmaceutical companies engaged in the synthesis of peptide mimetics, enzyme inhibitors, and other high-value chemical entities.

Application

• Pharmaceutical Intermediate: A critical building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and receptor modulators.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce fluorinated sulfonamide motifs, which can enhance metabolic stability and binding affinity.
• Peptidomimetic Synthesis: Serves as a non-natural amino acid derivative for constructing peptide analogs with improved pharmacological properties.
• Biochemical Probe Development: Utilized in the design and synthesis of chemical probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale GMP batches.

Basic Information

Product Name	Leucine, n-[(2-Fluorophenyl)Sulfonyl]-
CAS No.	1041437-98-2
Molecular Formula	C12H16FNO4S
Molecular Weight	289.32 g/mol
Synonyms	N-[(2-Fluorophenyl)sulfonyl]leucine; 2-Fluoro-N-(1-carboxy-4-methylpentyl)benzenesulfonamide; L-Leucine, N-[(2-fluorophenyl)sulfonyl]-; (S)-2-((2-Fluorophenyl)sulfonamido)-4-methylpentanoic acid; 2-Fluorobenzenesulfonamide leucine derivative; 1041437-98-2; Fluorophenyl sulfonyl leucine
EINECS	Contact for details

Quality Control

Our Leucine, n-[(2-Fluorophenyl)Sulfonyl]- is produced under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.