Description

R-3,3'-Bis(Triphenylsilyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2,2'-Naphthol CAS NO 1041186-22-4 is a sophisticated, sterically hindered chiral ligand and synthetic intermediate of significant importance in advanced organic synthesis. Its core value lies in its ability to induce high enantioselectivity in asymmetric catalytic reactions, a critical factor for producing optically pure pharmaceuticals and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity chiral auxiliaries to develop novel synthetic pathways and scale-up production processes.

Application

• As a chiral ligand in asymmetric metal-catalyzed reactions, including hydrogenation, hydrosilylation, and C-C bond-forming cross-couplings.
• Key intermediate in the multi-step synthesis of complex, biologically active molecules for pharmaceutical development.
• Utilized in the preparation of high-performance catalysts for the production of enantiomerically pure agrochemicals and flavors/fragrances.
• Research tool in academic and industrial laboratories for developing new methodologies in stereoselective synthesis.
• Component in the synthesis of novel materials with potential applications in chiral sensing and separation technologies.

Basic Information

Product Name	R-3,3'-Bis(Triphenylsilyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2,2'-Naphthol
CAS No.	1041186-22-4
Molecular Formula	C62H56O2Si2
Molecular Weight	889.29 g/mol
Synonyms	R-BINOL-TPS; (R)-3,3'-Bis(triphenylsilyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthol; (R)-H8-BINOL-3,3'-diyl bis(triphenylsilyl) ether; Octahydro-BINOL-TPS derivative; (R)-3,3'-Di(triphenylsilyl)-H8-BINOL; Asymmetric ligand 1041186-22-4; Chiral silicon-protected BINOL analog
EINECS	Contact for details

Quality Control

Our production of this advanced chiral compound adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques, including Chiral HPLC, 1H/13C NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess (ee), and identity is provided with every shipment, supporting your cGMP and quality-by-design (QbD) initiatives.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.