Description

Propargyl-Peg6-Ms is a heterobifunctional polyethylene glycol (PEG) linker featuring a propargyl group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry and a mesylate (Ms) leaving group for nucleophilic substitution. This compound is essential for constructing complex, well-defined bioconjugates, drug delivery systems, and advanced materials with precise control over architecture and functionality. It is primarily utilized by researchers and process developers in pharmaceutical R&D, bioconjugation, and materials science who require high-purity, functionalized PEG spacers.

Application

• Key reagent in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Functional linker for PEGylation of peptides, proteins, and oligonucleotides to enhance stability and pharmacokinetics.
• Building block for creating dendrimers, hydrogels, and smart polymer networks via click chemistry.
• Intermediate in the preparation of diagnostic probes and imaging agents for biomedical research.
• Surface modification of nanoparticles and drug delivery carriers to impart stealth properties and enable targeted ligand attachment.
• Tool compound in chemical biology for studying biomolecular interactions and cellular processes.
• Precursor for synthesizing specialized PEG-based crosslinkers and reagents used in assay development.

Basic Information

Product Name	Propargyl-Peg6-Ms
CAS No.	1036204-62-2
Molecular Formula	C20H36O10S
Molecular Weight	468.56 g/mol
Synonyms	Propargyl-PEG6-mesylate; 1-(Prop-2-yn-1-yloxy)-3,6,9,12,15,18-hexaoxahenicosan-21-yl methanesulfonate; mPEG6-Propargyl Mesylate; Propargyl-PEG6-OMs; Propargyl hexaethylene glycol monomethyl ether mesylate; Alkyne-PEG6-Ms; Propargyloxy-PEG6-mesylate; Heterobifunctional PEG Alkyne Mesylate
EINECS	Contact for details

Quality Control

Our Propargyl-Peg6-Ms is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Our quality commitment supports applications requiring GMP-grade intermediates and research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.