Description

2-(Bromomethyl)-1-Chloro-3-Iodobenzene is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique multi-halogen substitution pattern makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and as a precursor for functionalized materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring complex halogenated benzene cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the bromomethyl and iodo groups serve as handles for further functionalization.
• Material Science Research: Serves as a building block for creating organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its reactive halogen sites.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi couplings, leveraging the iodine and bromine atoms for selective metal-halogen exchange.
• Ligand and Catalyst Development: Employed in the preparation of specialized phosphine or nitrogen-based ligands for homogeneous catalysis.
• Chemical Biology Probes: Utilized to create tagged molecules or affinity probes for studying biological systems and target identification.

Basic Information

Item	Detail
Product Name	2-(Bromomethyl)-1-Chloro-3-Iodobenzene
CAS No.	1035263-31-0
Molecular Formula	C7H5BrClI
Molecular Weight	331.38 g/mol
Synonyms	1-Chloro-2-(bromomethyl)-3-iodobenzene; 3-Iodo-2-(bromomethyl)chlorobenzene; 2-Bromomethyl-1-chloro-3-iodobenzene; 1-Chloro-3-iodo-2-(bromomethyl)benzene; Benzene, 1-chloro-2-(bromomethyl)-3-iodo-; (2-Bromomethyl-1-chloro-3-iodo)benzene; 3-Iodo-2-bromomethylchlorobenzene
EINECS	Contact for details

Quality Control

Our 2-(Bromomethyl)-1-Chloro-3-Iodobenzene is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.