Description

tert-Butyl n-[4-(Hydroxymethyl)Oxan-4-Yl]Carbamate is a specialized carbamate-protected amino alcohol derivative, serving as a crucial chiral building block in advanced organic synthesis. Its value lies in the orthogonal protection of the amine and alcohol functionalities, enabling precise, multi-step synthetic sequences. This high-purity intermediate is primarily needed by pharmaceutical and fine chemical R&D teams for the development of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Peptidomimetic Chemistry: Used to incorporate constrained, heterocyclic amino acid analogs into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in catalytic asymmetric reactions to construct stereochemically defined molecules.
• Ligand and Catalyst Development: Serves as a precursor for novel chiral ligands used in transition metal catalysis.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group allows for selective deprotection under mild acidic conditions, facilitating complex multi-functional molecule assembly.
• Academic and Industrial Research: A valuable tool for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	tert-Butyl n-[4-(Hydroxymethyl)Oxan-4-Yl]Carbamate
CAS No.	1029716-09-3
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	tert-Butyl (4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)carbamate; 4-((tert-Butoxycarbonyl)amino)-4-(hydroxymethyl)tetrahydro-2H-pyran; 4-(Boc-amino)-4-(hydroxymethyl)tetrahydropyran; 4-(Hydroxymethyl)-4-((tert-butoxycarbonyl)amino)tetrahydro-2H-pyran; Boc-4-amino-4-(hydroxymethyl)tetrahydropyran; 1,1-Dimethylethyl N-[4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]carbamate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized and released based on a comprehensive analytical profile, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. We adhere to cGMP principles for pharmaceutical-grade intermediates. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.