Description

(1R,2S)-2-Amino-1-(2,3-Dihydrobenzo[B][1,4]Dioxin-6-Yl)Propan-1-Ol Hydrochloride is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound is valued for its defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) with specific biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly within the central nervous system (CNS) and cardiovascular domains.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly those targeting neurological and cardiovascular receptors.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the research and process development of new APIs requiring a specific (1R,2S) stereochemical configuration.
• Asymmetric Synthesis Research: Used in academic and industrial R&D to study and develop new asymmetric catalytic or enzymatic synthetic pathways.
• Reference Standard: Employed as a high-purity analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry Optimization: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.

Basic Information

Product Name	(1R,2S)-2-Amino-1-(2,3-Dihydrobenzo[B][1,4]Dioxin-6-Yl)Propan-1-Ol Hydrochloride
CAS No.	1028459-57-5
Molecular Formula	C₁₃H₁₈ClNO₃
Molecular Weight	271.74 g/mol
Synonyms	(1R,2S)-2-Amino-1-(1,4-benzodioxan-6-yl)-1-propanol hydrochloride; (1R,2S)-6-(2-Amino-1-hydroxypropyl)-1,4-benzodioxane hydrochloride; (1R,2S)-2-Amino-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propan-1-ol HCl; (1R,2S)-ADBP HCl; 1,4-Benzodioxan-6-yl(1R,2S)-2-amino-1-hydroxypropyl hydrochloride; Noradrenaline reuptake inhibitor intermediate; Chiral benzodioxane derivative
EINECS	Contact for details

Quality Control

Our (1R,2S)-2-Amino-1-(2,3-Dihydrobenzo[B][1,4]Dioxin-6-Yl)Propan-1-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, residual solvents, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (1R,2S) enantiomer
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.