Description

Potassium (2-Trimethylsilyl)-Ethoxymethyl Trifluoroborate is a specialized organoboron reagent, specifically a potassium trifluoroborate salt, widely used in modern synthetic chemistry. This compound is valued for its enhanced stability and handling properties compared to traditional boronic acids, making it a crucial building block for cross-coupling reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/alkyl halides and the protected boronate moiety, essential for synthesizing biaryl and heterobiaryl compounds.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for constructing complex, functionalized aromatic and heteroaromatic cores.
• Agrochemical Compound Development: Employed in creating novel herbicides, fungicides, and insecticides that require specific biaryl structures.
• Material Science & OLED Research: Serves as a precursor for synthesizing organic semiconductors, ligands for catalysts, and emissive materials in organic light-emitting diodes (OLEDs).
• Peptide Modification & Bioconjugation: The protected boronate functionality can be used for site-specific labeling and modification of peptides and other biomolecules.
• Library Synthesis for Drug Discovery: Enables high-throughput parallel synthesis of diverse compound libraries for screening in medicinal chemistry programs.

Basic Information

Product Name	Potassium (2-Trimethylsilyl)-Ethoxymethyl Trifluoroborate
CAS No.	1027642-28-9
Molecular Formula	C8H18BF3KOSi
Molecular Weight	274.23 g/mol
Synonyms	Potassium (2-(Trimethylsilyl)ethoxymethyl)trifluoroborate; Potassium (SEM)Trifluoroborate; (2-Trimethylsilyl)ethoxymethyltrifluoroborate Potassium Salt; Trifluoro((2-(trimethylsilyl)ethoxy)methyl)borate Potassium; Potassium Trifluoro(2-trimethylsilylethoxymethyl)borate; SEM-BF3K; K-SEM-BF3
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with high-purity standards for research and development. Each lot is characterized by multiple analytical techniques to confirm identity, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment and opened under an inert atmosphere (e.g., nitrogen or argon) for optimal long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (NMR)	≥ 95%
Assay (Potentiometric)	≥ 90% (as potassium trifluoroborate salt)
Water Content (KF)	≤ 2.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.