Description

2-Fluoro-5-((4-Oxo-3,4-Dihydrophthalazin-1-Yl)Methyl)Benzonitrile is a high-purity, advanced pharmaceutical intermediate featuring a unique fluorinated benzonitrile and phthalazinone hybrid structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule therapeutics targeting specific enzymatic pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of kinase inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for oncology and inflammatory disease targets.
• Kinase Inhibitor Development: Serves as a core scaffold or precursor in the research and production of potent and selective kinase inhibitors due to its phthalazinone moiety.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency, selectivity, and pharmacokinetic properties of lead compounds.
• Biochemical Probe Synthesis: Employed in creating specialized chemical probes for studying specific biological processes and target validation in cellular assays.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up synthesis under cGMP conditions for clinical trial material production.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	2-Fluoro-5-((4-Oxo-3,4-Dihydrophthalazin-1-Yl)Methyl)Benzonitrile
CAS No.	1021298-68-9
Molecular Formula	C₁₆H₁₀FN₃O
Molecular Weight	279.27 g/mol
Synonyms	1-[(4-Cyano-2-fluorophenyl)methyl]phthalazin-4(1H)-one; 2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile; 1021298-68-9; 1-[(4-Cyano-2-fluorobenzyl)]-4(1H)-phthalazinone; 2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzonitrile; 5-[(4-Oxo-3,4-dihydro-1-phthalazinyl)methyl]-2-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-((4-Oxo-3,4-Dihydrophthalazin-1-Yl)Methyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.