Description

Cyclobutylzinc Bromide 0.5M In Tetrahydrofuran is a versatile organozinc reagent, specifically a solution of cyclobutylzinc bromide in anhydrous tetrahydrofuran (THF). This product is essential for introducing the strained and valuable cyclobutyl moiety into target molecules via cross-coupling reactions, such as Negishi coupling. It is primarily used by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel compounds and active ingredients.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the construction of cyclobutane-containing drug candidates, leveraging the ring strain for biological activity.
• Negishi Cross-Coupling Reactions: Used to form carbon-carbon bonds with a wide range of aryl, heteroaryl, and vinyl halides in the presence of palladium catalysts.
• Agrochemical Research: Employed in the development of novel pesticides and herbicides that incorporate the cyclobutyl ring system.
• Material Science & Chemical Biology: Facilitates the synthesis of specialized ligands, monomers, and molecular probes containing the cyclobutyl group.
• Process Chemistry & Scale-up: Suitable for optimizing and scaling synthetic routes from laboratory to pilot plant scale due to its solution stability and handling.
• Asymmetric Synthesis: Can be used in conjunction with chiral ligands or catalysts to create enantiomerically enriched cyclobutyl derivatives.

Basic Information

Product Name	Cyclobutylzinc Bromide 0.5M In Tetrahydrofuran
CAS No.	1019205-65-2
Molecular Formula	C4H7BrZn (for Cyclobutylzinc Bromide); C4H8O (for THF solvent)
Molecular Weight	200.39 g/mol (for Cyclobutylzinc Bromide)
Synonyms	Cyclobutylzinc bromide THF solution; Zinc, bromocyclobutyl-; Bromocyclobutylzinc; Cyclobutane, 1-bromozincio-; Cyclobutylzinc bromide solution; 0.5M Cyclobutylzinc bromide in THF; Organozinc reagent solution; (Cyclobutyl)zinc bromide
EINECS	Contact for details

Quality Control

Every batch of Cyclobutylzinc Bromide 0.5M In Tetrahydrofuran is manufactured and tested under strict inert atmosphere conditions to ensure consistency and reactivity. Our quality assurance includes rigorous analysis for concentration, purity, and moisture content. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request, supporting compliance with internal quality standards and research documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, and well-ventilated area. Due to its properties of being easily oxidized (store under inert atmosphere), hygroscopic (moisture-sensitive), and highly volatile, the container must be kept sealed and handled under inert conditions to prevent degradation and maintain solution integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in Tetrahydrofuran
Assay (Titration)	≥ 0.45 M
Identification (IR)	Conforms
Water Content (KF)	≤ 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.