Description

(4S)-5,8-Difluoro-3,4-Dihydro-2H-Chromen-4-Amine is a high-purity chiral chromane derivative, serving as a critical advanced pharmaceutical intermediate and building block for medicinal chemistry research. Its value lies in its unique fluorinated, heterocyclic structure, which is essential for modulating the biological activity, metabolic stability, and physicochemical properties of target drug candidates. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the chromane scaffold with fluorine substituents.
• Asymmetric Synthesis: Employed in chiral synthesis due to its defined (4S) stereochemistry for creating enantiomerically pure compounds.
• Fluorinated Compound Library Synthesis: Serves as a core structure for generating diverse compound libraries in drug discovery programs.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme mechanisms or biological pathways.
• Academic & Contract Research: Used in university laboratories and CROs (Contract Research Organizations) for exploratory synthetic chemistry projects.

Basic Information

Product Name	(4S)-5,8-Difluoro-3,4-Dihydro-2H-Chromen-4-Amine
CAS No.	1018978-95-4
Molecular Formula	C9H9F2NO
Molecular Weight	185.17 g/mol
Synonyms	(4S)-5,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine; (4S)-5,8-Difluoro-3,4-dihydro-2H-chromen-4-amine; 2H-1-Benzopyran-4-amine, 5,8-difluoro-3,4-dihydro-, (4S)-; 5,8-Difluoro-3,4-dihydro-2H-chromen-4-amine (S-enantiomer); (S)-5,8-Difluoro-3,4-dihydro-2H-chromen-4-amine; 4-Amino-5,8-difluoro-3,4-dihydro-2H-chromene (S-form); Chromane-4-amine, 5,8-difluoro-, (4S)-
EINECS	Contact for details

Quality Control

Our (4S)-5,8-Difluoro-3,4-Dihydro-2H-Chromen-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC assay), chiral excess, and impurity profile is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.