Description

(4S)-6-Chloro-3,4-Dihydro-2H-Chromen-4-Amine is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic value. Its defined stereochemistry and functionalized chromane scaffold make it a critical precursor for the development of novel active pharmaceutical ingredients (APIs). This compound is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of potential therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug discovery programs.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in the preparation of enantiomerically pure compounds due to its defined (S)-configuration.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals for advanced material science and agrochemical research.
• Reference Standard: Can be supplied as a certified analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(4S)-6-Chloro-3,4-Dihydro-2H-Chromen-4-Amine
CAS No.	1018978-87-4
Molecular Formula	C9H10ClNO
Molecular Weight	183.63 g/mol
Synonyms	(4S)-6-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine; (S)-6-Chloro-3,4-dihydro-2H-chromen-4-amine; 6-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine, (4S)-; 1018978-87-4; (S)-6-Chloro-4-aminochroman; 4-Amino-6-chlorochroman, (S)-; (4S)-6-Chloro-4-amino-3,4-dihydro-2H-chromene
EINECS	Contact for details

Quality Control

Our (4S)-6-Chloro-3,4-Dihydro-2H-Chromen-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.