Description

(4R)-6-Chloro-3,4-Dihydro-2H-Chromen-4-Amine is a chiral chromane derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel pharmaceutical agents and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process chemistry, and the synthesis of complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Employed as a precursor or reagent in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical entities.
• Chemical Biology: Potential building block for the synthesis of molecular probes and tool compounds to study biological pathways.
• Process Development: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for target molecules.
• Academic Research: Valuable compound for methodological studies in organic chemistry, particularly those focusing on chromane and amine chemistry.

Basic Information

Product Name	(4R)-6-Chloro-3,4-Dihydro-2H-Chromen-4-Amine
CAS No.	1018978-86-3
Molecular Formula	C9H10ClNO
Molecular Weight	183.63 g/mol
Synonyms	(4R)-6-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine; (R)-6-Chloro-3,4-dihydro-2H-chromen-4-amine; 6-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine, (4R)-; 2H-1-Benzopyran-4-amine, 6-chloro-3,4-dihydro-, (4R)-; (4R)-6-Chloro-3,4-dihydro-2H-chromen-4-ylamine; (R)-6-Chloro-4-aminochroman
EINECS	Contact for details

Quality Control

Our (4R)-6-Chloro-3,4-Dihydro-2H-Chromen-4-Amine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is characterized by advanced analytical techniques including HPLC, GC, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.