Description

3-(Hydroxymethyl)Cyclobutanecarboxylic Acid is a versatile bifunctional organic compound featuring both a carboxylic acid and a hydroxymethyl group on a cyclobutane ring, making it a valuable chiral building block for advanced synthesis. This structure is particularly significant for its role in constructing complex, conformationally constrained molecules in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, fine chemical, and material science industries for applications such as intermediate synthesis and ligand development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially those requiring rigid, cyclobutane-based scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators with enhanced stereochemical specificity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Building Block: Employed in the multi-step synthesis of complex natural products, flavors, and fragrances.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for producing specialty polymers with unique thermal and mechanical properties.
• Academic & Industrial Research: A valuable tool in medicinal chemistry programs for structure-activity relationship (SAR) studies and probing new chemical space.

Basic Information

Product Name	3-(Hydroxymethyl)Cyclobutanecarboxylic Acid
CAS No.	1015856-00-4
Molecular Formula	C6H10O3
Molecular Weight	130.14 g/mol
Synonyms	3-(Hydroxymethyl)cyclobutanecarboxylic acid; (3-Hydroxymethylcyclobutyl)carboxylic acid; Cyclobutanecarboxylic acid, 3-(hydroxymethyl)-; 3-Carboxycyclobutanemethanol; 3-Hydroxymethyl-1-cyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Our 3-(Hydroxymethyl)Cyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.