Description

n-(2,3,5,6-Tetramethylphenylsulfonyl)Valine Monohydrate, 96% is a high-purity, protected amino acid derivative designed for advanced organic synthesis and pharmaceutical research. This compound serves as a critical building block for the development of novel peptides and bioactive molecules, offering a balance of reactivity and stability for complex coupling reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used as a protected valine derivative in solid-phase and solution-phase peptide synthesis (SPPS) to construct specific sequences.
• Bioconjugation: Employed in the modification of proteins, antibodies, or other biomolecules to introduce valine moieties or specific functional handles.
• Chemical Biology Research: Serves as a tool compound for studying enzyme-substrate interactions, metabolic pathways, and protein function.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for target molecules in fine chemical and agrochemical production.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and novel compound libraries.

Basic Information

Product Name	n-(2,3,5,6-Tetramethylphenylsulfonyl)Valine Monohydrate, 96%
CAS No.	1009595-18-9
Molecular Formula	C₁₅H₂₃NO₅S • H₂O
Molecular Weight	343.42 g/mol (Anhydrous basis: 325.41 g/mol)
Synonyms	N-(2,3,5,6-Tetramethylphenylsulfonyl)-L-valine Monohydrate; L-Valine, N-[(2,3,5,6-tetramethylphenyl)sulfonyl]-, monohydrate; TMPS-Val-OH • H₂O; 2,3,5,6-Tetramethylbenzenesulfonylvaline Monohydrate; N-TMPS-Valine Monohydrate; Protected Valine Derivative; (2S)-2-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-3-methylbutanoic acid monohydrate
EINECS	Contact for details

Quality Control

Our n-(2,3,5,6-Tetramethylphenylsulfonyl)Valine Monohydrate, 96% is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the specified 96% minimum purity and consistent performance for synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation and clumping.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 96.0%
Water Content (KF)	4.0% - 6.0% (Theoretical for monohydrate: ~5.25%)
Optical Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.