Description

4-Bromo-3-(trifluoromethoxy)benzoic acid 97% is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound matters because it provides a versatile scaffold for introducing bromine and trifluoromethoxy substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients, particularly in medicinal chemistry for lead optimization and structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic cores for electronic materials, contributing to improved performance in display technologies.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Peptidomimetics & Bioisosteres: The benzoic acid moiety is utilized in designing peptidomimetics and as a bioisostere for other carboxylic acid-containing structures in drug design.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating specialized chemical libraries for screening.

Basic Information

Product Name	4-Bromo-3-(trifluoromethoxy)benzoic Acid 97%
CAS No.	1008769-87-6
Molecular Formula	C8H4BrF3O3
Molecular Weight	285.02 g/mol
Synonyms	4-Bromo-3-(trifluoromethoxy)benzoic acid; 3-Trifluoromethoxy-4-bromobenzoic acid; Benzoic acid, 4-bromo-3-(trifluoromethoxy)-; 4-Bromo-alpha,alpha,α-trifluoro-m-anisic acid; 4-Bromo-3-trifluoromethoxybenzoic acid; 4-Bromo-3-OCF3-benzoic acid
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-(trifluoromethoxy)benzoic acid 97% undergoes rigorous quality testing to ensure compliance with industry standards for research and development. We implement strict in-process controls and final release testing, including identity confirmation and purity verification. Certificates of Analysis (COA) with batch-specific data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive (hygroscopic); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.