Description

1-(Indane-5-Sulfonyl)-Pyrrolidine-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonamide-pyrrolidine carboxylic acid structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of protease inhibitors, receptor antagonists, and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new chemical entities (NCEs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Protease Inhibitor Scaffold: Serves as a core structural component in the design and synthesis of potential inhibitors for various enzymes like caspases or matrix metalloproteinases (MMPs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to improve potency and pharmacokinetic properties.
• Peptidomimetic Development: Employed to create novel peptidomimetics, where the indane-sulfonyl-pyrrolidine moiety mimics peptide turn structures.
• Chemical Biology Probe Synthesis: Utilized as a starting material for creating tool compounds to study specific biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied for custom synthesis projects requiring this specific, high-value molecular framework under cGMP or research-grade conditions.

Basic Information

Product Name	1-(Indane-5-Sulfonyl)-Pyrrolidine-2-Carboxylic Acid
CAS No.	1008069-92-8
Molecular Formula	C14H17NO4S
Molecular Weight	295.35 g/mol
Synonyms	1-(2,3-Dihydro-1H-indene-5-sulfonyl)pyrrolidine-2-carboxylic acid; 2-Pyrrolidinecarboxylic acid, 1-[(2,3-dihydro-1H-inden-5-yl)sulfonyl]-; 1-(Indan-5-ylsulfonyl)-L-proline (enantiomer specific); 5-Indanesulfonyl-proline; Indane-5-sulfonyl proline derivative; (S)-1-((2,3-Dihydro-1H-inden-5-yl)sulfonyl)pyrrolidine-2-carboxylic acid; Proline, 1-(indan-5-ylsulfonyl)-; 1008069-92-8
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of 1-(Indane-5-Sulfonyl)-Pyrrolidine-2-Carboxylic Acid is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. We adhere to strict in-house specifications suitable for research and development applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.