Description

N,N''-(1R)-[1,1'-Binaphthalene]-2,2'-Diylbis[N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea is a sophisticated chiral thiourea derivative, recognized for its role as a highly effective organocatalyst and chiral selector. Its value lies in its ability to facilitate asymmetric synthesis with excellent enantioselectivity, a critical requirement in modern pharmaceutical and fine chemical development. This compound is essential for research chemists and process development scientists working in asymmetric catalysis, chiral resolution, and the synthesis of enantiomerically pure intermediates for active pharmaceutical ingredients (APIs).

Application

• Asymmetric Organocatalysis: Employed as a chiral hydrogen-bond donor catalyst for a variety of enantioselective transformations, including Michael additions, Mannich reactions, and acylations.
• Chiral Resolution & Analysis: Used in the development of chiral stationary phases (CSPs) for HPLC or as a chiral derivatizing agent to separate and analyze enantiomers.
• Pharmaceutical Intermediate Synthesis: A key building block or catalyst in the multi-step synthesis of complex, single-enantiomer drug molecules.
• Material Science Research: Investigated for the creation of chiral functional materials, sensors, and supramolecular assemblies due to its well-defined stereochemistry and binding properties.
• Academic & Industrial R&D: Serves as a benchmark compound in methodological studies for developing new catalytic asymmetric protocols.

Basic Information

Product Name	N,N''-(1R)-[1,1'-Binaphthalene]-2,2'-Diylbis[N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea
CAS No.	1005003-43-9
Molecular Formula	C42H24F12N4S2
Molecular Weight	876.79 g/mol
Synonyms	(R)-3,3'-Bis[3,5-bis(trifluoromethyl)phenyl]-1,1'-binaphthyl-2,2'-diylbis(thiourea); (R)-BINOL-Derived Bis(thiourea) Catalyst; (R)-TRIP-Thiourea; Chiral Bis(thiourea) Organocatalyst; (R)-1,1'-Binaphthalene-2,2'-diyl bis[N'-(3,5-bis(trifluoromethyl)phenyl)thiourea]; (R)-BINAP-Thiourea Analogue; Takemoto Catalyst Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced chiral compound adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques, including Chiral HPLC, 1H/19F NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC assay), enantiomeric excess (ee), and impurity profile is provided with every shipment, supporting cGMP development and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.