Description

(S,E)-1-Phenyl-n-(4-(Trifluoromethyl)Benzylidene)-2-(Trimethylsilyloxy)Ethanamine is a high-value, chiral organosilicon compound featuring a trifluoromethylphenyl moiety, designed for advanced synthetic applications. Its core value lies in serving as a sophisticated building block or chiral auxiliary in the synthesis of complex molecules, particularly within pharmaceutical research and fine chemical production. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require precise stereochemical control and fluorinated intermediates.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for enhanced metabolic stability.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group and specific stereochemistry can influence biological activity.
• Asymmetric Synthesis: Acts as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce high enantioselectivity.
• Material Science Precursor: Potential monomer or additive in the development of specialty polymers and advanced materials with unique surface properties.
• Organic Synthesis Research: Versatile reagent for constructing complex molecular architectures in academic and industrial R&D laboratories.
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) in medicinal chemistry due to its defined stereochemistry and fluorine content.

Basic Information

Item	Details
Product Name	(S,E)-1-Phenyl-n-(4-(Trifluoromethyl)Benzylidene)-2-(Trimethylsilyloxy)Ethanamine
CAS No.	1003887-64-6
Molecular Formula	C19H22F3NOSi
Molecular Weight	365.47 g/mol
Synonyms	(S,E)-N-[(4-(Trifluoromethyl)phenyl)methylene]-1-phenyl-2-(trimethylsilyloxy)ethanamine; (S,E)-1-Phenyl-2-(trimethylsilyloxy)-N-[4-(trifluoromethyl)benzylidene]ethanamine; (S,E)-α-(Trimethylsilyloxy)benzylidene-4-(trifluoromethyl)benzylamine; TMS-protected Chiral Trifluoromethyl Imine; (S,E)-N-(4-Trifluoromethylbenzylidene)-α-(trimethylsilyloxy)benzylamine
EINECS	Contact for details

Quality Control

Our (S,E)-1-Phenyl-n-(4-(Trifluoromethyl)Benzylidene)-2-(Trimethylsilyloxy)Ethanamine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.