Description

(S)-8-Fluorochroman-4-Amine is a chiral, fluorinated chroman derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex molecules targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in neuroscience and psychiatry.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its fluorinated chroman scaffold.
• Asymmetric Synthesis: Employed as a chiral amine component in catalytic asymmetric reactions to introduce stereogenic centers.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.
• Chemical Biology Probes: Utilized in the design of molecular probes to study biological pathways and enzyme functions.

Basic Information

Product Name	(S)-8-Fluorochroman-4-Amine
CAS No.	1003887-62-4
Molecular Formula	C9H10FNO
Molecular Weight	167.18 g/mol
Synonyms	(4S)-8-Fluoro-3,4-dihydro-2H-1-benzopyran-4-amine; (S)-8-Fluoro-3,4-dihydro-2H-chromen-4-amine; (S)-8-Fluorochroman-4-ylamine; 8-Fluoro-(4S)-chroman-4-amine; (4S)-8-Fluorochroman-4-amine; (S)-4-Amino-8-fluorochroman; 1003887-62-4; (S)-8-Fluoro-3,4-dihydro-2H-1-benzopyran-4-amine
EINECS	Contact for details

Quality Control

Our (S)-8-Fluorochroman-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.