Description

tert-Butyl 2-(4-aminophenyl)morpholine-4-carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique morpholine and protected amine functionalities. This compound is of critical importance for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and oncology therapeutics. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in process development and scale-up for novel drug candidates.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the production of sophisticated pharmaceutical compounds, especially those targeting neurological pathways.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design, optimization, and synthesis of new chemical entities (NCEs) during drug discovery phases.
• Process Chemistry & Scale-Up: Employed in pilot plants and manufacturing settings to develop robust and scalable synthetic routes for candidate drugs.
• Precursor for Biologically Active Molecules: The protected amine and morpholine structure make it a versatile precursor for molecules with potential receptor-binding activity.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	tert-Butyl 2-(4-Aminophenyl)morpholine-4-carboxylate
CAS No.	1002726-96-6
Molecular Formula	C15H22N2O3
Molecular Weight	278.35 g/mol
Synonyms	4-[[(tert-Butoxy)carbonyl]morpholin-2-yl]aniline; 2-(4-Aminophenyl)-N-Boc-morpholine; tert-Butyl 2-(4-aminophenyl)morpholine-4-carboxylate; 4-(4-Aminophenyl)-2-morpholinecarboxylic acid 1,1-dimethylethyl ester; N-Boc-2-(4-aminophenyl)morpholine; 1002726-96-6; 2-(4-Aminophenyl)morpholine-4-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(4-aminophenyl)morpholine-4-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with client specifications and current industry standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.