Description

2-Bromo-4-(Difluoromethoxy)Aniline is a specialized aromatic amine derivative featuring both bromine and difluoromethoxy substituents. This compound serves as a versatile and high-value building block in advanced organic synthesis, enabling the introduction of unique halogenated and fluorinated motifs. It is primarily required by pharmaceutical, agrochemical, and advanced material research sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance bioavailability and metabolic stability.
• Liquid Crystal & OLED Material Research: Used in the development of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Functional Dye & Pigment Chemistry: Intermediate for creating specialized dyes and pigments with altered light-fastness and solubility properties.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) for constructing complex biaryl structures.
• Chemical Biology & Proteomics: Can be utilized as a tagging or labeling reagent for probing biological systems due to its reactive aniline group.

Basic Information

Product Name	2-Bromo-4-(Difluoromethoxy)Aniline
CAS No.	1000574-79-7
Molecular Formula	C7H6BrF2NO
Molecular Weight	238.03 g/mol
Synonyms	4-(Difluoromethoxy)-2-bromoaniline; 2-Bromo-4-(difluoromethoxy)benzenamine; 1-Amino-2-bromo-4-(difluoromethoxy)benzene; Benzenamine, 2-bromo-4-(difluoromethoxy)-; 2-Bromo-4-difluoromethoxyaniline; 2-Br-4-(OCF2H)C6H3NH2
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(Difluoromethoxy)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to guarantee batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after initial use to minimize exposure to atmospheric moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.