Description

2-Cyanobenzylzinc Bromide is a versatile organozinc reagent, a key building block in modern synthetic organic chemistry. Its value lies in enabling efficient carbon-carbon bond formation, particularly in Negishi cross-coupling reactions, which are critical for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for introducing the ortho-cyanobenzyl moiety into target molecules during the research and development of new active pharmaceutical ingredients (APIs).
• Negishi Cross-Coupling Reactions: Used as a nucleophilic coupling partner with various aryl, heteroaryl, and vinyl halides or triflates to form new C-C bonds with high selectivity.
• Agrochemical Compound Development: Employed in the synthesis of novel herbicides, fungicides, and insecticides that require specific benzyl-substituted structures.
• Ligand and Catalyst Preparation: Serves as a precursor in the synthesis of specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Utilized in the creation of organic electronic materials, such as novel polymers or small molecules for OLEDs and semiconductors.
• Academic & R&D Laboratories: A valuable tool for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	2-Cyanobenzylzinc Bromide
CAS No.	199465-66-2
Molecular Formula	C8H6BrNZn
Molecular Weight	261.44 g/mol
Synonyms	(2-Cyanobenzyl)zinc bromide; Zinc, bromo(2-cyanophenyl)methyl-; Bromo(2-cyanobenzyl)zinc; (o-Cyanobenzyl)zinc bromide; 2-Cyanobenzylzinc bromide solution; Bromo(2-cyanophenyl)methylzinc; (2-Cyanophenyl)methylzinc bromide
EINECS	Contact for details

Quality Control

Our 2-Cyanobenzylzinc Bromide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as concentration (typically supplied as a solution in THF or other solvents), zinc content, and impurity profile. Our quality system is designed to meet the rigorous standards required for research, development, and scale-up activities in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at recommended temperatures between 2°C and 8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and highly volatile; ensure containers are kept sealed and handled in a well-ventilated area or glovebox to prevent exposure to air and moisture, which can degrade the reagent.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in THF (or as specified)
Assay (Titration)	≥ 95%
Identification (NMR)	Conforms to structure
Water Content (KF)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.