Description

(4S,5S)-2-Chloro-1,3-Dimethyl-4,5-Diphenyl-1-Imidazolinium Chloride is a high-value, chiral imidazolinium salt that serves as a critical building block and catalyst precursor in advanced organic synthesis. Its significance lies in its well-defined stereochemistry and structural rigidity, which are essential for inducing enantioselectivity in complex chemical transformations. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals where precise stereochemical control is paramount.

Application

• Asymmetric Organocatalysis: Acts as a precursor for generating N-heterocyclic carbene (NHC) catalysts used in enantioselective reactions like benzoin condensations and Stetter reactions.
• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders.
• Ligand Synthesis: Used to prepare chiral ligands for transition metal catalysis, enhancing selectivity in cross-coupling and hydrogenation reactions.
• Academic & Industrial Research: A valuable tool for method development in synthetic organic chemistry, enabling the exploration of new catalytic pathways.
• Fine Chemical Production: Employed in the manufacture of high-value specialty chemicals where its chiral framework imparts specific functional properties.

Basic Information

Product Name	(4S,5S)-2-Chloro-1,3-Dimethyl-4,5-Diphenyl-1-Imidazolinium Chloride
CAS No.	198625-67-1
Molecular Formula	C₁₇H₁₈Cl₂N₂
Molecular Weight	329.24 g/mol
Synonyms	(4S,5S)-2-Chloro-1,3-dimethyl-4,5-diphenyl-4,5-dihydro-1H-imidazol-3-ium chloride; (4S,5S)-2-Chloro-1,3-dimethyl-4,5-diphenylimidazolidinium chloride; Chiral Imidazolinium Salt; NHC Precursor Salt; (S,S)-2-Chloro-1,3-dimethyl-4,5-diphenylimidazolinium chloride
EINECS	Contact for details

Quality Control

Our (4S,5S)-2-Chloro-1,3-Dimethyl-4,5-Diphenyl-1-Imidazolinium Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the stringent requirements of research and pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.